Research use only — not for human consumption. Not evaluated by the MHRA or FDA.
Peptides
KPV 10mg
10 mg · Lyophilised powder
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| Form | Lyophilised powder |
|---|---|
| Purity specification | ≥ 99% by HPLC (supplier specification) |
| Storage | −20°C lyophilised · 2–8°C once reconstituted |
Research Overview
What KPV is
KPV is a tripeptide with the sequence Lys-Pro-Val, corresponding to the three C-terminal residues (11–13) of alpha-melanocyte-stimulating hormone (α-MSH). It has a molecular weight of approximately 342 Da, making it one of the smallest compounds in the Megalab range. Because it lacks the residues responsible for melanocortin receptor binding, KPV has been studied as a means of separating certain activities of the parent hormone from its pigmentation effects.
Research background
KPV appears in the literature primarily in models of inflammation. Published work includes mouse models of colitis, cell-culture studies of NF-κB signalling in epithelial and immune cells, and investigations of its transport across intestinal epithelium via the peptide transporter PepT1. Its very short sequence has also made it a useful subject for studies of peptide stability and delivery. Megalab supplies KPV as a laboratory reagent only.
Specification
Each vial contains 10mg of KPV as a lyophilised powder. Purity is verified by HPLC at ≥99% on every batch. The batch record on this page identifies the current lot where published, and a Certificate of Analysis is available on request.
Analytical notes
Given its low molecular weight, 10mg of KPV represents a comparatively large molar quantity (roughly 29 µmol). Researchers preparing molar stock solutions should account for this when selecting diluent volumes; the peptide calculator on this site returns mass concentration, which can be converted using the molecular weight above.
Handling and storage
Store unopened vials at −20°C, protected from light. Bring to room temperature before opening. KPV dissolves readily; add bacteriostatic water down the vial wall and swirl gently. Store reconstituted solution at 2–8°C and use within 30 days.
Supplied for laboratory research use only.
Reconstitution & storage
- Diluent
- Bacteriostatic water, added slowly down the inside wall of the vial; swirl, do not shake.
- Lyophilised
- Store at −20°C, away from light and moisture.
- Reconstituted
- Refrigerate at 2–8°C.
Frequently Asked Questions
How is KPV related to α-MSH?
KPV is the C-terminal tripeptide of α-MSH, residues 11 to 13. It retains part of the parent hormone’s sequence but not the region responsible for melanocortin receptor binding.
Why does 10mg of KPV go further than 10mg of a larger peptide?
Molar quantity depends on molecular weight. At roughly 342 Da, 10mg of KPV is about 29 µmol, several times the molar amount in 10mg of a 2,000 Da peptide.
What purity and documentation come with KPV?
Every batch is released at ≥99% purity by HPLC, with the current lot shown in the batch record and a full Certificate of Analysis available on request.
